Unforeseen Consequences of Therapy With Continuous-Flow Pumps

Unforeseen consequences of therapy with continuous-flow pumps.

Editor’s Introduction: Unforeseen Consequences of Policy Decisions

It is almost a truism that populations affect their environment, and that environments constrain populations. Yet as we work to elucidate the actual workings of these interactions, we are often surprised. This issue of Population and Environment focuses on unforeseen or unintended consequences of policy. Often, centralized government policies are specifically directed at affecting people’s repr...

Progressive multifocal leukoencephalopathy and natalizumab--unforeseen consequences.

In this issue of the Journal, there are reports describing in detail three patients in whom progressive multifocal leukoencephalopathy (PML) developed during treatment with natalizumab, a humanized monoclonal antibody against a 4 integrins. 1-3 These patients were among 3000 who had participated in clinical trials of natalizumab for the treatment of multiple sclerosis or Crohn’s disease. PML is...

Continuous subcutaneous insulin infusion therapy: A primer on insulin pumps.

OBJECTIVE To summarize the role, benefits, and risks of continuous subcutaneous insulin infusion (CSII) therapy for treating diabetes. DATA SOURCES A literature search was conducted in Medline (1996 to July 2008) using the search terms intensive insulin therapy, insulin pump, and continuous subcutaneous insulin infusion. Reference lists from comprehensive review articles were also used to ide...

Electroosmotic flow pumps with polymer frits

Electroosmotic flow (EOF) pumps with flow rates on the order of 1 ml/min have been designed and fabricated. These pumps use EOF to propel liquid solutions in a compact system with no moving parts. The pumping chamber is filled with densely packed non-porous silica particles, and the particle bed is held in place using two polymeric porous frits. The pump frame is made of acrylic, the frits are ...